Treatment of intracellular infection

Details Treatment of intracellular infection Treatment of intracellular infection

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2372078

An agent for combatting an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery of the phage into the target cell. Once inside the target cell, the phage causes lysis of a microorganism residing within the target cell. A mycobacteriophage is combined with a targeting moiety of transferrin. Compositions comprising the agent, methods of preparing said agent, and use of said agent for combatting intracellular infections are also provided.

L'invention concerne un agent destiné à combattre une infection microbienne intracellulaire, qui comprend un composant bactériophage et, associée à ce dernier, une fraction de ciblage qui dirige l'agent vers une cellule cible et amorce la diffusion du bactériophage dans cette cellule. Une fois qu'il se trouve à l'intérieur de la cellule cible, le bactériophage provoque la lyse d'un micro-organisme résidant dans ladite cellule. Un mycobactériphage est associé à une fraction de ciblage de transferrine. L'invention concerne également des compositions renfermant l'agent de la présente invention, des procédés de préparation dudit agent, et l'utilisation de ce dernier pour combattre les infections intracellulaires.

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