A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/225 (2006.01) A61K 31/00 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/22 (2006.01) A61K 31/223 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01)
Patent
CA 2396533
A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.
L'invention concerne un procédé de réduction du stress oxydatif dans le cerveau d'un organisme possédant une barrière hémato-encéphalique et souffrant d'une lésion ischémique cérébrale, ce procédé comprenant l'étape consistant à administrer à l'organisme concerné un composé comprenant: (a) une combinaison de propriétés relatives au poids moléculaire et à la miscibilité membranaire, lesquelles permettent au composé de traverser la barrière hémato-encéphalique de l'organisme, (b) un groupe chimique pouvant s'oxyder facilement et destiné à exercer des propriétés antioxydantes, et (c) un complément chimique permettant une accumulation, dans le cytoplasme des cellules, du composé ou du dérivé intracellulaire de celui-ci.
Atlas Daphne
Melamed Eldad
Offen Daniel
Mor - Research Applications Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ramot University Authority For Applied Research & Industrial Dev
Yissum Research Development Company Of The Hebrew University Of
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