Treatment of ischemic diseases using erythropoietin

A - Human Necessities – 61 – K

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Details

A61K 38/22 (2006.01) A61K 35/14 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2654154

A method for the regeneration of a blood vessel, comprising the steps of: (a) administering erythropoietin to a subject; (b) collecting a peripheral blood mononuclear cell from the subject; and (c) administering the collected peripheral blood mononuclear cell to a desired site in the subject. When erythropoietin is administered to a subject, a peripheral blood mononuclear cell (particularly a CD34-positive one) is recruited into the peripheral blood of the subject. The method is useful for the treatment of an ischemic disease such as peripheral vascular disorder.

La présente invention concerne un procédé de régénération d'un vaisseau sanguin qui comprend les étapes suivantes : (a) administration d'érythropoïétine à un sujet ; (b) prélèvement d'une cellule mononucléée du sang périphérique chez le sujet ; et (c) administration en un site choisi chez le sujet de la cellule mononucléée du sang périphérique prélevée. Quand de l'érythropoïétine est administrée à un sujet, une cellule mononucléée du sang périphérique (en particulier une cellule CD34-positive) est recrutée dans le sang périphérique du sujet. Le procédé est utilisable pour le traitement d'une maladie ischémique telle qu'une affection vasculaire périphérique.

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