A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2367025
A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need therof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
La présente invention concerne un procédé permettant de réduire la survenue de la fièvre, de la céphalée, des nausées et/ou du vomissement associé à l'administration d'un composé thérapeutique à un mammifère justifiant d'un tel traitement. En l'occurrence, on administre à ce mammifère une première dose posologique de conditionnement faite d'un composé de déplétion des cellules non cibles qui se lie à un récepteur cellulaire superficiel d'une cellule mammalienne cible. On administre ensuite une seconde dose posologique thérapeutique du composé, cette seconde dose posologique étant plus élevée que la première dose posologique.
Dedrick Russell L.
Garovoy Marvin R.
Kramer Susan M.
Starko Karen
Genentech Inc.
Smart & Biggar
Xoma Technology Ltd.
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