Treatment of lipid and glucose metabolism disorders with...

A - Human Necessities – 61 – K

Patent

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A61K 31/48 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2257084

The present invention relates to novel, improved methods for regulating in a mammal at least one of body weight, body fat, food consumption, lipid metabolism and glucose metabolism. Administration of a D1 or D2 agonist or both in the morning, combined with administration of a 5HT1B receptor subtype agonist at night results in reduction in food consumption, body weight, serum glucose levels and total body fat.

L'invention concerne de nouvelles méthodes améliorées qui permettent la régulation chez un mammifère d'au moins une des caractéristiques suivantes: poids du corps, teneur en graisses du corps, consommation d'aliments, métabolisme des lipides et métabolisme du glucose. L'administration d'un agoniste D1 ou D2 ou de ces deux agonistes, le matin, en combinaison avec l'administration d'un agoniste du sous-type du récepteur 5HT1B la nuit, se traduit par la réduction de la consommation de nourriture, du poids du corps, des taux de glucose sérique et de la teneur totale en graisses du corps.

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