Treatment of meconium aspiration syndrome with estrogens

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/565 (2006.01) A61K 9/02 (2006.01) A61K 9/08 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2691654

One aspect of the present invention relates to the use of an estrogen in the treatment of Meconium Aspiration Syndrome (MAS) in a newborn infant,said treatment comprising administering an effective amount of estrogen to said newborn infant within 7 days after birth. The present treatment offers the advantage that estrogens can be administered using non-invasive modes of administration, e.g. oral or rectal administration. Other aspects of the present invention relate to a suppository for use in newborn infants comprising at least 1 µg of estrogen and to an oral applicator comprising a container holding an aqueous liquid containing micronised estetrol and a metering dispenser for metering the liquid into the oral cavity of a newborn infant.

La présente invention, sous un aspect, concerne l'utilisation d'un strogène dans le traitement du syndrome d'aspiration méconiale (MAS) chez un nouveau-né. Ce traitement comporte l'administration d'une quantité efficace d'strogène audit nouveau-né dans les 7 jours de la naissance. Le présent traitement offre l'avantage que les strogènes peuvent être administrés à l'aide de modes d'administration non invasifs, par exemple par administration orale ou rectale. D'autres aspects de la présente invention concernent un suppositoire destiné à être utilisé chez des nouveau-nés, comportant au moins 1 µg d'strogène, et un applicateur oral comportant un récipient contenant un liquide aqueux contenant de l'estétrol micronisé et un distributeur doseur pour mesurer le liquide à l'intérieur de la cavité buccale d'un nouveau-né.

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