Treatment of metastatic breast cancer

Details Treatment of metastatic breast cancer Treatment of metastatic breast cancer

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/337 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2671223

The present invention concerns treatment of previously untreated HER2-positive metastatic breast cancer with a combination of a growth inhibitory HER2 antibody, a HER2 dimerization inhibitor antibody and a taxene. In particular, the invention concerns the treatment of HER2-positiv metastatic breast cancer in patients who did not receive prior chemotherapy or biologic therapy with a HER2 antibody binding essentially to epitope 2C4, a HER2 antibody binding essentially to epitope 4D5, and a taxene. The invention further comprises extending survival of such patients by the combination therapy of the present invention. In a preferred embodiment, the treatment involves administration of trastuzumab, pertuzumab and docetaxel.

La présente invention concerne le traitement de cancer du sein métastasique HER2-positif non précédemment traité avec une combinaison d'un anticorps anti-HER2 inhibiteur de croissance, d'un anticorps inhibiteur de dimérisation de HER2 et d'un taxane. En particulier, l'invention concerne le traitement de cancer du sein métastasique HER2-positif chez des patients qui n'ont pas reçu une chimiothérapie ou une thérapie biologique antérieure avec un anticorps anti-HER2 se liant essentiellement à l'épitope 2C4, un anticorps anti-HER2 se liant essentiellement à l'épitope 4D5, et un taxane. L'invention comprend en outre la prolongation de la survie de tels patients par la thérapie d'association de la présente invention. Dans un mode de réalisation préféré, le traitement met en oevre l'administration de trastuzumab, de pertuzumab et de docétaxel.

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