C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/16 (2006.01) A61K 31/00 (2006.01) A61K 38/16 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2380888
The present invention is directed to compounds and methods for the treatment of metastatic disease. The compounds of this invention have specificity for EphA2, an epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. The compounds used in accordance with this invention may be provided in a pharmaceutical composition for treatment of metastatic disease.
La présente invention concerne des composés et des procédés destinés au traitement de maladies métastatiques. Ces composés présentent une spécificité pour l'EphA2, une tyrosine-kinase de cellule épithéliale surexprimée dans les cellules de tumeurs métastatiques. En outre, ces composés utilisés selon l'invention peuvent être introduits dans une composition pharmaceutique destinée au traitement de maladies métastatiques.
Hein Patrick W.
Kilpatrick Katherine E.
Kinch Michael Scott
Zantek Nicole Dodge
Glaxo Group Limited
Purdue Research Foundation
Smart & Biggar
The University Of North Carolina At Chapel Hill
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