C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/31 (2006.01) A61K 38/16 (2006.01) A61K 39/085 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01) C07K 14/75 (2006.01)
Patent
CA 2713241
The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immuno-genic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, includ-ing Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM- like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
La présente invention concerne des vaccins antigéniques microbiens améliorés, des compositions pharmaceutiques, des compositions immunogènes et des anticorps ainsi que leur utilisation dans le traitement d'infections microbiennes telles que, notamment, celles d'origine bactérienne, y compris celles d'origine staphylococcique. Idéalement, la présente invention concerne une protéine MSCRAMM ou de type MSCRAMM staphylococcique recombinante, ou un fragment de celle-ci, présentant une liaison réduite à son ligand hôte, à utiliser à des fins thérapeutiques.
Foster Timothy
Geoghegan Joan
Higgins Judy
Josefsson Elisabet
Tarowski Andrej
Near Dublin The Provost Fellows And Scholars Of The College Of The Holy And
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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