Treatment of mood/affective disorders by glutamatergic...

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Patent

CA 2250856

Affective disorders in humans are treated by enhancing glutamatergic transmission. This is achieved in various ways, one of which is by the administration of a class of therapeutic agents having a phenyl ketone- containing molecular structure and similar to the structure of aniracetam. This discovery is based on tests using REM sleep reduction in an animal model as an indicator.

On traite les désordres affectifs chez l'homme en renforçant la transmission glutamatergique. Pour ce faire plusieurs méthodes sont possibles, notamment l'administration d'une classe d'agents thérapeutiques présentant une structure moléculaire contenant du phénylcétone, semblable à la structure de l'aniracétam. Cette découverte est fondée sur des essais portant sur la réduction du sommeil paradoxal chez un modèle animal servant d'indicateur.

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