Treatment of mucus hypersecretion

Details Treatment of mucus hypersecretion Treatment of mucus hypersecretion

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2341429

A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a compound that inhibits exocytosis in mucus secreting cells or neurones that control or direct mucus secretion. Also described is a compound, for use in the treatment of hypersecretion of mucus, which inhibits mucus secretion by inhibiting mucus secretion by mucus secreting cells, and/or inhibiting neurotransmitter release from neuronal cells controlling or directing mucus secretion.

L'invention concerne une méthode de traitement de l'hypersécrétion de mucus, facteur causal de la bronchopneumopathie chronique obstructive (COPD), de l'asthme et d'autres états cliniques impliquant la COPD. Ladite méthode consiste à administrer un composé qui inhibe l'exocytose dans les cellules sécrétant le mucus ou les neurones qui commandent ou dirigent la sécrétion de mucus. L'invention porte également sur un composé à utiliser dans le traitement de l'hypersécrétion de mucus, qui inhibe la sécrétion de mucus en inhibant la sécrétion de mucus par les cellules sécrétant le mucus, et/ou en inhibant la libération de neurotransmetteur des cellules neuronales commandant ou dirigeant la sécrétion de mucus.

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