Treatment of multiple sclerosis and/or rheumatoid arthritis

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2648330

The invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament utilized for the treatment of multiple sclerosis and/or rheumatoid arthritis in a subject that is preferably a primate or a human. In another embodiment, the invention relates to the use of an antibody which can specifically bind to chemokine receptor CCR2 for producing a medicament that is utilized for depleting monocytes in subjects suffering from multiple sclerosis and/or rheumatoid arthritis. The invention further relates to corresponding in vitro methods and therapeutic methods. An antibody which binds to CD 14, for example, can be used in addition to the antibody that can bind to CCR2.

La présente invention concerne l'utilisation d'un anticorps qui peut se lier spécifiquement au récepteur de chimiokine CCR2, pour la fabrication d'un médicament destiné à traiter la sclérose en plaques et / ou la polyarthrite rhumatoïde chez un sujet. De préférence, ledit sujet est un primate ou un être humain. Dans un autre mode de réalisation, la présente invention concerne l'utilisation d'un anticorps qui peut se lier spécifiquement au récepteur de chimiokine CCR2, pour la fabrication d'un médicament pour la destruction de monocytes chez un sujet atteint de sclérose en plaques et / ou de polyarthrite rhumatoïde. La présente invention concerne également des procédés correspondants in vitro et des méthodes thérapeutiques. En plus de l'anticorps qui peut se lier à CCR2, il est possible d'utiliser également un anticorps pouvant se lier, par exemple, à CD14.

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