Treatment of multiple sclerosis (ms) with campath-1h

Details Treatment of multiple sclerosis (ms) with campath-1h Treatment of multiple sclerosis (ms) with campath-1h

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2662531

A method for treatment of multiple sclerosis (MS) with Campath-1H with significant efficacy and a favourable safety profile is described, which offers an acceptable benefit/risk ratio. Especially described is the use of Campath-1H (alemtuzumab) for the production of a medicament for the treatment of multiple sclerosis (MS), comprising a first treatment cycle followed by at least one further treatment cycle of Campath-1H (alemtuzumab), in which each treatment cycle comprises 1-5 daily doses which are applied on consecutive days, wherein the daily dose is >0 and <= 12 mg, and wherein each treatment cycle is separated from the next cycle by at least 1 - 24 months. Also described are treatment regimens comprising the administration of less than 12 mg/day of Campath-1H for a period of 1-5 consecutive days.

L'invention concerne un procédé pour le traitement de la sclérose en plaques (MS) par le Campath-1 H présentant une efficacité significative et un profil de sécurité favorable, qui offre un rapport bénéfice/risque acceptable. L'invention concerne en particulier l'utilisation du Campath-1 H (alemtuzumab) pour la production d'un médicament pour le traitement de la sclérose en plaques (MS), comprenant un premier cycle de traitement suivi d'au moins un autre cycle de traitement par le Campath-1 H (alemtuzumab), dans lequel chaque cycle de traitement comprend 1-5 doses quotidiennes qui sont appliquées pendant des jours consécutifs, la dose quotidienne étant > 0 et <= 12 mg, et dans lequel chaque cycle de traitement est séparé du cycle suivant par au moins 1-24 mois. L'invention concerne également des régimes de traitement comprenant l'administration de moins de 12 mg/jour de Campath-1 H pendant une période de 1-5 jours consécutifs.

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