A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5415 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2735714
A method of administering meloxicam containing compositions to neonate foals of 6 weeks of age or less is provided. The inventors have discovered that foals of 6 weeks of age or less can have meloxicam administered at a dosage of 0.6 mg/kg without any negative or adverse reaction by the foal. The method also provides a dosing regimen for obtaining first peak plasma concentrations of approximately 800ng/ml, average plasma concentration levels of 200ng/ml for 6 hours after a single dose, and sustained plasma concentration levels of 100ng/ml with twice daily dosing.
L'invention porte sur un procédé d'administration de compositions contenant du méloxicam à des poulains nouveaux-nés âgés de six semaines ou moins. Les inventeurs ont établi que les poulains âgés de six semaines ou moins peuvent se voir administrer du méloxicam à un dosage de 0,6 mg/kg sans aucune réaction négative ou secondaire de la part du poulain. Le procédé fournit également un régime de dosage permettant d'obtenir des pics de premières concentrations dans le plasma d'approximativement 800 ng/ml, des taux moyens de concentration dans le plasma de 200 ng/ml pendant 6 heures après une dose unique, et des taux entretenus de concentration dans le plasma de 100 ng/ml avec un dosage biquotidien.
Pippia Giuseppe
Raidal Sharanne
Clark Wilson Llp
Troy Laboratories Pty. Ltd.
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