A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 31/14 (2006.01) A61K 31/155 (2006.01) A61K 31/165 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/245 (2006.01) A61K 31/365 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/417 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/455 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/539
Patent
CA 2404858
In some aspects, the invention relates to treatments for peptide aggregation associated with disease states such as neurodegenerative disease, particularly physiology associated with Alzheimer's Disease, and non-neurodegenerative disease aggregation. Other aspects of the invention also provides a variety of novel assays for screening candidate drugs. Yet another aspects of the present invention also provides a series of compositions useful for treatment of neurological disease as determined from these assays. These compositions can be packaged in kits. Other aspects of the invention also relate to the use of these compositions for the treatment and/or prevention of patients susceptible to or exhibiting of a disease characteristic of fibril formation or aberrant protein aggregation.
L'invention concerne le traitement de l'agrégation de peptides associée aux états pathologiques tels que les maladies neurodégénératives, en particulier la physiologie associée à la maladie d'Alzheimer, et l'agrégation des maladies non neurodégénératives. L'invention concerne également de nouvelles analyses de criblage de médicaments candidats. L'invention concerne en outre une série de compositions utilisées dans le traitement des maladies neurologiques conformément aux résultats desdites analyses. Ces compositions peuvent se présenter sous forme de kits. L'invention concerne également l'utilisation de ces compositions dans le traitement et/ou la prévention de patients susceptibles de présenter ou présentant une maladie se caractérisant par la formation de fibrilles ou une agrégation protéique aberrante.
Bamdad Cynthia C.
Bamdad R. Shoshanna
Minerva Biotechnologies Corporation
Sim & Mcburney
LandOfFree
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