Treatment of neurodegenerative disease through intracranial...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61M 25/00 (2006.01) A61M 37/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2565098

The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site in a brain, and discharging through the discharge portion of the catheter a predetermined dosage of at least one substance capable of inhibiting production of at least one neurodegenerative protein. The present invention also provides valuable small interfering RNA vectors, and methods for treating neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Spinocerebellar Ataxia Type l, Type 2, Type 3, and/or dentatorubral- pallidoluysian atrophy.

L'invention concerne des dispositifs, des petits ARN interférents, ainsi que des méthodes de traitement d'un trouble neurodégénératif qui consistent à implanter chirurgicalement un cathéter de manière à ce qu'une partie de décharge du cathéter repose à proximité d'un site de perfusion prédéterminé dans le cerveau, et à décharger à travers la partie de décharge du cathéter une dose prédéterminée d'au moins une substance capable d'inhiber la production d'au moins une protéine neurodégénérative. Par ailleurs, l'invention concerne des vecteurs de petits ARN interférents, ainsi que des méthodes de traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer, la maladie de Parkinson, la maladie de Huntington, l'ataxie spinocérébelleuse de type 1, de type 2, et de type 3, et/ou l'atrophie dentaturo-rubro-pallido-luysienne.

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