Treatment of neurodegenerative diseases by the use of atp7a...

Details Treatment of neurodegenerative diseases by the use of atp7a... Treatment of neurodegenerative diseases by the use of atp7a...

C - Chemistry, Metallurgy

12

N

C12N 9/14 (2006.01) A61K 31/713 (2006.01) C12N 15/11 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2554362

The invention relates to the use of a ATP7A-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby the ATP7A-interacting molecule is preferably an inhibitor of ATP7A and particularly it has the capacity to modulate the activity of gamma-secretase and/or beta-secretase. Furthermore the invention concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator comprising the following steps: a. identifying of a ATP7A- interacting molecule by determining whether a given test compound is a ATP7A- interacting molecule, b. determining whether the ATP7A-interacting molecule of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.

La présente invention se rapporte à une molécule interagissant avec ATP7A, qui permet de préparer une composition pharmaceutique destinée à traiter une maladie neurodégénérative. Selon l'invention, ladite molécule interagissant avec ATP7A est de préférence un inhibiteur de ATP7A, et a en particulier la capacité de moduler l'activité de la gamma secrétase et/ou de la bêta secrétase. En outre, l'invention concerne un procédé permettant d'identifier un modulateur de la gamma secrétase et/ou de la bêta secrétase, qui comprend les étapes consistant : a) à identifier une molécule interagissant avec ATP7A, en déterminant si un composé d'essai donné est une molécule interagissant avec ATP7A ; b) à déterminer si la molécule interagissant avec ATP7A de l'étape a) est capable de moduler l'activité de la gamma secrétase et/ou de la bêta secrétase.

Affiliated with

Also associated with

Rating

Treatment of neurodegenerative diseases by the use of atp7a... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of neurodegenerative diseases by the use of atp7a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of neurodegenerative diseases by the use of atp7a... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1561505