Treatment of neurological conditions using complement c5a...

Details Treatment of neurological conditions using complement c5a... Treatment of neurological conditions using complement c5a...

A - Human Necessities

61

K

A61K 38/12 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2560902

This invention relates to the treatment of neurological conditions with novel cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of C5a receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes, monocytes, lymphocytes and/or macrophages. In a preferred form of the invention the neurological conditions are neurodegenerative diseases, neuroimmunological disorders, diseases arising from dysfunction of the blood brain barrier, and stroke.

L'invention porte sur le traitement de conditions neurologiques au moyen de nouveaux composés peptidiques et peptidomimétiques cycliques capables de moduler l'activité des récepteurs C5a. Ces composés agissent, de préférence, en tant qu'antagonistes du récepteur C5a, et sont actifs contre les lymphocytes et/ou macrophages. Dans une forme préférée de l'invention, les conditions neurologiques sont des maladies neurodégénérescentes, des troubles neuro-immunologiques, des maladies dues à un dysfonctionnement de la barrière hémato-encéphalique, et des attaques cardiaques.

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