Treatment of neurotrophic factor mediated disorders

Details Treatment of neurotrophic factor mediated disorders Treatment of neurotrophic factor mediated disorders

A - Human Necessities

61

K

A61K 31/58 (2006.01) A61P 17/02 (2006.01) A61P 17/16 (2006.01) A61P 17/18 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2750510

An agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof is used to induce self- regulated homeostasis of neurotrophic factors(NFs), for example BDNF and/or GDNF, NFs with limited and manageable side effects in a subject, by modulating NFs in a non- toxic manner under homeostatic control. An effective amount of at least one such agent is administered to the subject, particularly in the treatment or prevention of a range of NF- mediated disorders, particularly neurological, psychiatric, inflammatory,allergic,immune and neoplastic disorders, and in the restoration or normalisation of neuronal and other function in or in relation to any damaged or abnormal tissue, including when assisting tissue (for example, skin, bone, eye and muscle) healing and general skin, bone, eye and muscle health.

L'invention concerne l'utilisation d'un agent appartenant au groupe qui comprend les sapogénines stéroïdiennes du type A/B-cis-furostane, furostène, spirostane et spirostène, et leurs formes esters, éthers, cétones et glycosylées pour induire une homéostasie autorégulée des facteurs neurotrophiques(NF), par exemple BDNF et/ou GDNF, NF à effets secondaires limités et gérables chez un sujet, en modulant les NF d'une manière non toxique sous un contrôle homéostatique. On administre au sujet une quantité efficace d'au moins un de ces agents, particulièrement dans le traitement ou la prévention de tout un éventail de troubles médiés par NF, particulièrement les troubles neurologiques, psychiatriques, inflammatoires, allergiques, immunitaires et néoplasiques, et dans la restauration ou la normalisation d'une fonction neuronale ou autre en relation avec tout tissu endommagé ou anormal, y compris pour une assistance à la cicatrisation tissulaire (par exemple, peau, os, yeux et muscles) et pour la santé générale de la peau, des os, des yeux et des muscles.

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