A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01)
Patent
CA 2183954
The present invention is directed to 5-HT2 antagonists end their use as agents in the treatment of obsessive-compulsive disorders (OCD). The invention is particularly directed to the compound (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol which is a member of a class of 5-HT2 antagonists known as N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5-HT2 receptor site.
La présente invention se rapporte à des antagonistes de 5-HT2 et à leur utilisation comme agents dans le traitement des psychonévroses obsessionnelles. L'invention se rapporte notamemnt au composé (+)- alpha -(2,3-diméthoxyphényl)-1-[2-(4-fluorophényl)éthyl]-4-piperidineméthanol, élément d'une classe d'antagonistes 5-HT2 connus comme étant des dérivés de N-aralkyle piperidineméthanol, lesquels sont des inhibiteurs puissants et sélectifs de la fixation de la sérotonine sur le site du récepteur 5-HT2.
Kehne John H.
Padich Robert A.
Schmidt Christopher J.
Aventisub II Inc.
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
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