Treatment of ophthalmic disorders using urea and urea...

A - Human Necessities – 61 – K

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A61K 31/17 (2006.01) A61K 31/155 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2475338

Methods for treating disorders of the eye and/or disorders of a nerve in a human or veterinary patient by delivering to the patient a therapeutically effective amount of a compound selected from the group of; urea, urea derivatives, thiourea, thiourea derivatives, guanidine, guanidine derivatives and compounds having General Formula I as set forth herein. For ophthalmic applications, the compound may be delivered by intravitreal injection such that the compound causes vitreal liquefaction, posteriour vitreoretinal detachment and other affects.

La présente invention concerne des méthodes de traitement des troubles des yeux et/ou des troubles des nerfs chez un homme ou un animal, qui consistent à administrer à un patient, une quantité thérapeutiquement efficace d'un composé sélectionné dans le groupe formé par l'urée, les dérivés d'urée, la thio-urée, les dérivés de thio-urée, la guanidine, les dérivés de guanidine et les composés représentés par la formule (I) selon l'invention. Pour des applications ophtalmiques, le composé peut être administré par injection intravitréenne de telle sorte que le composé provoque la liquéfaction vitréenne, le détachement vitréo-rétinien postérieur et d'autres effets.

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