A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61K 38/12 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2542513
This invention relates to methods of treatment of osteoarthritis, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.
La présente invention concerne des procédés permettant un traitement de l'arthrose, et plus particulièrement le traitement de cet état au moyen de composés peptidomimétiques et peptides cycliques capables de moduler l'activité des récepteurs couplés à la protéine G. Ces composés, qui agissent de préférence en antagonistes du récepteur C5a, sont actifs contre les récepteurs C5a sur les leucocytes polymorphonucléaires et les macrophages. L'invention concerne également des composés préférés convenant pour l'invention.
Fairlie David
Shiels Ian Alexander
Gowling Lafleur Henderson Llp
Promics Pty Limited
The University Of Queensland
LandOfFree
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