Treatment of ovarian cancer using an anticancer agent...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 31/337 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2759129

Ovarian cancer is treated with conjugates of an anticancer agent and an Angiopep-2 polypeptide analog (i.e. a polypeptide comprising an ammo acid sequence at least 80% identical to Seq. ID NO:97). Such treatment includes utility in treating metastatic ovarian cancer and in treating patients who have previously exhibited resistance to standard chemotherapeutic agents. Preferred anticancer agents include taxanes while the preferred conjugate is ANG1005, a conjugate comprising three molecules of paclitaxel conjugated to the peptide Angiopep-2.

Selon l'invention, un cancer de l'ovaire est traité avec des conjugués d'un agent anticancéreux et d'un analogue polypeptidique d'Angiopep-2 (c'est-à-dire un polypeptide comportant une séquence d'acides aminés identique à au moins 80 % à SEQ ID NO : 97). Un tel traitement s'utilise dans le traitement d'un cancer de l'ovaire métastasique et dans le traitement de patients qui ont présenté précédemment une résistance à des agents chimiothérapiques classiques. Les agents anticancéreux préférés comprennent des taxanes alors que le conjugué préféré est ANG1005, un conjugué comportant trois molécules de paclitaxel conjuguées au peptide Angiopep-2.

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