Treatment of pain with gap junction modulation compounds

Details Treatment of pain with gap junction modulation compounds Treatment of pain with gap junction modulation compounds

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2727015

The present invention relates to delivery, including transdermal delivery, of a therapeutically effective amount of a compound useful for modulating gap junction formation and function, including an oligonucleotide for reducing gap junction for-mation and function, and methods and compositions for treating a subject suffering from pain associated with a disease, disorder or condition and associated with pain, including but not limited to muscle pain, ligament pain, tendon pain, joint pain and postoperative pain.

La présente invention porte sur l'administration, comprenant une administration transdermique, d'une quantité thérapeutique efficace d'un composé utile pour moduler la formation et la fonction d'une jonction communicante, comprenant un oligonucléotide pour réduire la formation et la fonction d'une jonction communicante, et sur des procédés et des compositions pour traiter un sujet souffrant de douleur associée à une maladie, un trouble ou un état associé à la douleur, comprenant, mais sans y être limité, la douleur musculaire, la douleur des ligaments, la douleur des tendons, la douleur des articulations et la douleur post-opératoire.

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