C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/99 (2006.01) A01N 33/26 (2006.01) A01N 37/18 (2006.01) A01N 43/78 (2006.01) C07C 241/00 (2006.01) C07C 281/06 (2006.01) C07C 311/29 (2006.01) C07D 207/273 (2006.01) C07D 213/56 (2006.01) C07D 277/60 (2006.01) C07D 295/215 (2006.01) C07D 307/22 (2006.01) C07D 401/00 (2006.01) C07D 409/12 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C12N 9/48 (2006.01)
Patent
CA 2327282
The present invention relates to compounds and pharmaceutical compositions which inhibit proteases, such as cysteine proteases. In particular, the present invention relates to compounds and pharmaceutical compositions which inhibit cysteine proteases of the papain superfamily. The compounds and pharmaceutical compositions of the present invention are useful for treating diseases, particularly parasitic diseases, which are mediated by such proteases. In particular, the present invention relates to a method of treating malaria by inhibiting the cysteine protease falcipain.
L'invention concerne des composés et des compositions pharmaceutiques qui inhibent les protéases, telles que les cystéine-protéases. Elle porte notamment sur des composés et des compositions pharmaceutiques qui inhibent les cystéine-protéases de la superfamille de la papaïne. Les composés et les compositions pharmaceutiques de l'invention sont utiles pour le traitement de maladies, en particulier de maladies parasitaires, induites par lesdites protéases. Elle se rapporte encore à une méthode de traitement de la malaria par l'inhibition de la cystéine-protéase appelée falcipaïne.
Tew David Graham
Thompson Scott Kevin
Tomaszek Thaddeus Anthony
Veber Daniel Frank
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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