A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01)
Patent
CA 2614321
The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar and a calicheamicin-antibody conjugate, such as Mylotarg. The invention is also directed to pharmaceutical formulations comprising zosuquidar and calicheamicin-antibody conjugates. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML) and metastatic breast cancer.
La présente invention concerne une méthode de traitement de patients atteints de tumeurs solides, de leucémies, et autres tumeurs malignes à l'aide d'une combinaison de zosuquidar et d'un conjugué de calichéamicine et d'anticorps, tel que le Mylotarg. L'invention concerne également des compositions pharmaceutiques comprenant du zosuquidar et des conjugués de calichéamicine et d'anticorps. Lesdites préparations sont particulièrement efficaces pour le traitement de la leucémie myélogène aiguë (LMA) récidivante et le cancer du sein métastatique.
Glenn Scott
Hoth Daniel
Marcelletti John
Multani Pratik S.
Sikic Branimir
Gowling Lafleur Henderson Llp
Kanisa Pharmaceuticals Inc.
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