Treatment of proliferative disorders

Details Treatment of proliferative disorders Treatment of proliferative disorders

G - Physics

01

N

G01N 33/574 (2006.01) A61K 31/40 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2617642

The application discloses a method of identifying compound for the treatment of proliferative disorders that comprises testing compounds for its binding affinity to clAP-1. Preferentially compounds are selected which have a higher affinity for clAP-1 than for XIAP. In a related method, compounds causing faster degradation of clAP-1 than of XIAP are identified. Identified compounds can be peptidomimetics of the N-terminal four amino acids of SMAC. Furthermore, the application discloses methods and compositions for the treatment of proliferative diseases using compounds with the above described clAP-1 binding properties.

La présente invention concerne des inhibiteurs de cIAP-1 ainsi que des méthodes et des compositions utiles pour traiter les maladies prolifératives.

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