C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/78 (2006.01) A61K 31/357 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4433 (2006.01) A61K 31/69 (2006.01) A61K 31/7105 (2006.01) A61K 38/45 (2006.01) A61K 51/00 (2006.01) C07D 319/06 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C12N 15/55 (2006.01) C12Q 1/00 (2006.01) C12Q 1/34 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2601706
The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
L'invention porte sur des procédés de traitement de troubles liés à la dégradation de protéines, tels que des troubles de prolifération cellulaire (par exemple le cancer) et des troubles liés au dépôt de protéines (par exemple des maladies neurodégénérescentes). Cette invention concerne des procédés et des compositions pharmaceutiques de traitement de ces maladies au moyen d'inhibiteurs d'aggresome et d'inhibiteurs de proteasome. Cette invention se rapporte aussi à des procédés et des compositions pharmaceutiques de traitement du myélome multiple. Elle porte également sur de nouveaux inhibiteurs HDAC/TDAC et sur des inhibiteurs d'aggresome, ainsi que sur des procédés synthétiques de préparation de ces composés.
Anderson Kenneth C.
Bradner James Elliott
Greenberg Edward Franklin
Haggarty Stephen J.
Hideshima Teru
Dana-Farber Cancer Institute Inc.
President And Fellows Of Harvard College
Robic
LandOfFree
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