Treatment of pulmonary arterial hypertension

Details Treatment of pulmonary arterial hypertension Treatment of pulmonary arterial hypertension

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2732789

The present invention pertains to the use of 4-(4-methylpiperazin-1-ylmethyl)- N-[4-methyl-3-(4-pyridin-3-yl) pyrimidin-2-ylamino)phenyl]-benzamide or a pharmaceutically acceptable salt thereof or a pyrimidylaminobenzamide of formula I wherein the radicals and symbols are as defined herein, or a pharmaceutically acceptable salt thereof, for the manufacture of medicament for treating pulmonary arterial hypertension (PAH), especially in patients who failed prior PAH therapy.

La présente invention concerne lutilisation du 4-(4-méthylpipérazin-1-yl-méthyl)-N-[4-méthyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phényl]-benzamide ou de lun de ses sels pharmaceutiquement acceptables ou dun pyrimidylaminobenzamide de formule I dans laquelle les radicaux et les symboles sont tels que définis dans ce document, ou de lun de ses sels pharmaceutiquement acceptables, pour la fabrication dun médicament destiné au traitement de lhypertension artérielle pulmonaire (HAP), spécialement chez les patients pour lesquels un traitement antérieur de la HAP a échoué.

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