Treatment of pulmonary disorders with aerosolized...

A - Human Necessities – 61 – K

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A61K 9/08 (2006.01) A61K 38/14 (2006.01) A61M 15/00 (2006.01)

Patent

CA 2700534

A method of administering an aerosolized anti-infective, such as a glycopeptide, to the respiratory system of a patient. A ratio of an amount of the glycopeptide, such as vancomycin, delivered to the pulmonary system of the patient in a 24 hour period to a minimum inhibitory amount for the target organ for the same period is about 2 or more. A system to introduce aerosolized medicament to a patient may include a humidifier coupled to an inspiratory limb of a ventilator circuit wye, where the humidifier supplies heated and humidified air to the patient, and an endotracheal tube having a proximal end coupled to a distal end of the ventilator circuit wye. The system may also include a nebulizer coupled to the endotracheal tube, where the nebulizer generates the aerosolized medicament.

L'invention porte sur un procédé d'administration d'un aérosol anti-infectieux, tel qu'un glycopeptide, au système respiratoire d'un patient. Le rapport d'une quantité du glycopeptide, tel que la vancomycine, administrée au système pulmonaire du patient en une période de 24 heures sur une quantité inhibitrice minimale pour l'organe cible pendant la même période est d'environ au moins 2. Un système pour introduire un aérosol médicamenteux chez un patient peut comprendre un humidificateur couplé à un élément inspiratoire d'un raccord de circuit de ventilateur, l'humidificateur fournissant de l'air chauffé et humidifié au patient, et un tube trachéal ayant une extrémité proximale couplée à une extrémité distale du raccord de circuit de ventilateur. Le système peut également comprendre un nébuliseur couplé au tube trachéal, le nébuliseur générant l'aérosol médicamenteux.

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