Treatment of refractory tumors using epothilone derivatives

Details Treatment of refractory tumors using epothilone derivatives Treatment of refractory tumors using epothilone derivatives

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/395 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01)

Patent

CA 2438610

Methods of treating tumors in a mammal, especially a human that has demonstrated resistance to other chemotherapeutic agents, is disclosed. Specifically, methods of the present invention are effective in tumors that have initially been unresponsive to taxane therapy, or have developed resistance during the course of treatment. The methods of the present invention comprise administering epothilone derivatives selected from those represented by the formula. The subject epothilone derivatives are advantageous in addition to their enhanced potency and effectiveness against tumors that have demonstrated resistance to therapy with taxane oncology agents in that they are efficacious upon oral administration.

L'invention concerne des procédés de traitement des tumeurs chez un mammifère, notamment un être humain présentant une résistance à d'autres agents chimiothérapeutiques. Ces procédés sont efficaces contre les tumeurs qui ont été initialement réfractaires au traitement à base de taxane ou qui ont développé une résistance au cours du traitement. Les procédés consistent à administrer un dérivé d'épothilone choisi parmi ceux représentés par la formule I: [figure chimique]. Les dérivés d'épothilone de l'invention possèdent une capacité et une efficacité améliorées contre les tumeurs présentant une résistance au traitement à l'aide d'agents oncologiques à base de taxane et une efficacité avantageuse lorsqu'ils sont administrés oralement.

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