A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2574709
The present invention relates to methods and compositions for the treatment, management, or prevention of multiple myeloma and/or renal dysfunction in mammals. The methods of the invention comprise the administration of an effective amount of one or more pituitary adenylate cyclase activating polypeptide ("PACAP") compounds, which includes PACAP, vasoactive intestinal peptide ("VIP"), their agonists, analogs, fragments, or derivatives, having one or more PACAP activities. The invention also provides pharmaceutical compositions comprising one or more PACAP compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents useful in therapy for the treatment, management, or prevention of multiple myeloma and/or renal dysfunction.
La présente invention concerne des méthodes et des compositions de traitement, de gestion ou de prévention du myélome multiple et/ou du dysfonctionnement rénal chez des mammifères. Les méthodes de l'invention consistent en l'administration d'une dose efficace d'un ou de plusieurs composés du polypeptide pituitaire activateur de l'adnénylate cyclase ("PACAP") renfermant PACAP, un peptide vasoactif intestinal ("VIP"), leurs antagonistes, analogues, fragments dérivés présentant une ou plusieurs activités PACAP. L'invention concerne également des compositions pharmaceutiques renfermant un ou plusieurs composés PACAP de l'invention, soit seul soit en combinaison avec un ou plusieurs autres agents prophylactiques/thérapeutiques utiles en thérapie pour le traitement, la gestion ou la prévention du myélome multiple et/ou du dysfonctionnement rénal.
Arimura Akira
Li Min
Osler Hoskin & Harcourt Llp
Tulane University Health Sciences Center
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