A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61K 31/495 (2006.01) A61P 13/00 (2006.01)
Patent
CA 2448449
The present invention relates to compositions containing quinazolinones. More particularly, the present invention relates to a composition for treatment renal fibrosis, comprising as active ingredient a quinazolinone derivative as herein defined. The currently preferred embodiment is halofuginone, which is now show to slow or prevent progression of renal fibrosis in vivo, thereby preventing end-stage renal failure.
L'invention concerne des compositions contenant des quinazolinones. L'invention concerne, plus particulièrement, une composition permettant de traiter une fibrose rénale, qui comprend un dérivé de quinazolinone comme ingrédient actif. Le mode de réalisation actuellement préféré est un halofuginone qui ralentit ou empêche la progression d'une fibrose rénale <i>in vivo</i>, ce qui prévient une insuffisance rénale en stage terminal.
Nagler Arnon
Pines Mark
Vlodavsky Israel
Yarkoni Shai
Agricultural Research Organiza Tion State Of Israel Ministry Of Agriculture
Collgard Biopharmaceuticals Ltd.
Hadasit Medical Research Services And Development Ltd.
Ridout & Maybee Llp
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