Treatment of respiratory disease associated with matrix...

A - Human Necessities – 61 – K

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A61K 31/405 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2526222

The present invention encompasses methods and compositions for the treatment and prevention of respiratory diseases associated with matrix metalloproteases. More specifically, the present invention relates to the treatment and prevention of respiratory diseases associated with matrix metalloproteases by inhalation of synthetic matrix metalloprotease inhibitors. Exemplary respiratory diseases associated with matrix metalloproteases that may be treated by the methods of the invention include chronic obstructive pulmonary disease, emphysema, asthma, cystic fibrosis, and chronic bronchitis. An exemplary synthetic matrix metalloprotease useful in the methods of the invention is ilomastat.

La présente invention concerne des procédés et des compositions permettant de traiter et de prévenir des maladies respiratoires induites par les métalloprotéases matricielles. Plus spécifiquement, la présente invention concerne le traitement et la prévention de maladies respiratoires induites par les métalloprotéases matricielles, par inhalation d'inhibiteurs de synthèse des métalloprotéases matricielles. Des exemples de maladies respiratoires induites par les métalloprotéases matricielles pouvant être traitées selon les procédés présentés sont la maladie obstructive respiratoire chronique, l'emphysème, l'asthme, la fibrose cystique et la bronchite chronique. Un exemple d'inhibiteur de synthèse des métalloprotéases matricielles utilisé dans lesdits procédés est l'ilomastat.

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