A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2546649
The invention encompasses a novel method of treating inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases and their clinical symptoms. The inventors have made the discovery that the activity of HIF- 1.alpha., a transcription regulator known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of HIF- 1.alpha..
L'invention concerne une nouvelle méthode de traitement de maladies inflammatoires, telles que la polyarthrite rhumatoïde, ainsi que de nouvelles méthodes d'identification et de criblage de médicaments utiles pour le traitement de maladies inflammatoires et de leurs symptômes cliniques. On a découvert que l'activité de HIF-1.alpha., régulateur de transcription connu pour exercer un effet sur certains cancers, joue un rôle important dans la pathophysiologie de la polyarthrite rhumatoïde. Il est possible de soulager les symptômes d'une maladie inflammatoire, telle que la polyarthrite rhumatoïde, par administration d'un composé inhibant l'activité de HIF-1.alpha..
Defranoux Nadine
Hurez Vincent Jacques
Michelson Seth G.
Shoda Lisl Katharine
Wennerberg Leif Gustaf
Entelos Inc.
Smart & Biggar
LandOfFree
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