Treatment of rumen acidosis with .alpha.-amylase inhibitors

A - Human Necessities – 61 – K

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A61K 31/715 (2006.01) A23K 1/16 (2006.01) A23K 1/18 (2006.01) A61K 31/702 (2006.01) A61K 31/7036 (2006.01) A61P 1/04 (2006.01) C12Q 1/34 (2006.01) C12Q 1/40 (2006.01)

Patent

CA 2348245

The invention described herein relates to: the use of an effective inhibitor of a bacterial .alpha.--amylase and/or .alpha.-glucosidase in the manufacture of a composition for the treatment of acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial .alpha.-amylase and/or .alpha.-glucosidase to a ruminant; a formulation suitable for the treatment of acidosis in an animal which comprises an effective inhibitor of a bacterial .alpha.-amylase and/or .alpha.-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical / veterinary / farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial .alpha.-amylase and/or .alpha.-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial .alpha.-amylase and/or .alpha.-glucosidase; a compound of the formula I: (see formula I) or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial .alpha.-amylase and/or .alpha.- glucosidase useful for the treatment of acidosis in a ruminant.

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