A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/54 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2306817
This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. In a particular aspect, the invention relates to methods for the use of AMPA receptor up-modulators in conjunction with antipsychotics for the treatment of schizophrenia. Kits containing the compositions in appropriate form for administration are also provided. The figure shows that a representative Ampakine (CX516) synergistically enhances clozapine antagonism of methamphetamine-induced rearing activity.
L'invention concerne un traitement de la schizophrénie et des troubles psychotiques associés, produisant une amélioration du fonctionnement des récepteurs synaptiques des circuits neuronaux responsables des comportements d'ordre supérieur. Dans un aspect particulier, l'invention concerne des méthodes de traitement de la schizophrénie comprenant l'utilisation de stimulants du récepteur AMPA associés à des antipsychotiques. L'invention concerne en outre des kits comprenant ces compositions présentées sous une forme appropriée à l'administration. Le dessin montre qu'une ampakine (Cx516) améliore synergiquement l'antagonisme de la clozapine de l'activité de culture induite par méthamphétamine.
Johnson Steven A.
Lynch Gary S.
Rogers Gary A.
Cortex Pharmaceuticals Inc.
Fetherstonhaugh & Co.
The Regents Of The University Of California
LandOfFree
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