Treatment of septic shock with conjugated biologically...

C - Chemistry – Metallurgy – 07 – K

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C07K 7/04 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01) C07K 9/00 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01)

Patent

CA 2151046

A compound which is a conjugate of a biologically active amphiphilic peptide and a conjugate moiety. The conjugate moiety may be a carbohydrate (such as dextran or hetastarch); a protein; polyvinyl pyrrolidone, a polyalkylene glycol; or polyvinyl alcohol. Such compounds neutralize bacterial endotoxins, and thus are particularly useful in the treatment or prevention of septic shock.

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