Treatment of sexual dysfunction

Details Treatment of sexual dysfunction Treatment of sexual dysfunction

A - Human Necessities

61

K

A61K 31/27 (2006.01) A61P 15/00 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2612672

This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

Procédé de traitement de dysfonctionnement sexuel : administration de quantité thérapeutiquement efficace de composé de formule (I), y compris un sel ou ester correspondant pharmaceutiquement acceptable, sachant que Rx peut être hydrogène, alkyle inférieur avec 1 à 8 atomes de carbone, halogène comme F, CI, Br et I, alcoxy avec 1 à 3 atomes de carbone, nitro, hydroxy, trifluorométhyle, et thioalcoxy avec 1 à 3 atomes de carbone; x est un entier compris entre 1 et 3, à condition que R puisse être identique ou différent lorsque x vaut 2 ou 3; R1 et R2 peuvent être identiques ou différents et sont indépendamment hydrogène, alkyle inférieur avec 1 à 8 atomes de carbone, aryle, arylalkyle, cycloalkyle avec 3 à 7 atomes de carbone; R1 et R2 peuvent être assemblés pour former un hétérocycle avec 5 à 7 éléments, substitué avec un élément pouvant être hydrogène, alkyle, et groupes aryle, sachant que le composé cyclique peut comporter 1 ou 2 atomes d'azote et 0 ou 1 atome d'oxygène ; les atomes d'azote ne sont pas directement liés entre eux ou avec l'atome d'oxygène.

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