Treatment of systematic fungal infections with phospholipid...

Details Treatment of systematic fungal infections with phospholipid... Treatment of systematic fungal infections with phospholipid...

A - Human Necessities

61

K

167/163, 167/180

A61K 9/51 (2006.01) A61K 9/127 (2006.01)

Patent

CA 1292184

ABSTRACT Formulations consisting of phospholipid small unila- mellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about .2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the anti- fungal antibiotic to treat systemic fungal infections.

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