Treatment of t cell mediated autoimmune disorders

Details Treatment of t cell mediated autoimmune disorders Treatment of t cell mediated autoimmune disorders

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223303

Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper effector functions, for example, an anti-gp39 antibody.

L'invention concerne un procédé de traitement de la sclérose en plaques et d'autres maladies auto-immunes induites par les lymphocytes T. Ce procédé consiste à administrer à un sujet une dose thérapeutique efficace d'un antagoniste d'un récepteur sur la surface des lymphocytes T qui assure la médiation de la fonction d'effecteur auxiliaire activé par contact, par exemple d'un anticorps anti-récepteur gp39.

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