Treatment of t-cell mediated diseases

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01)

Patent

CA 2523467

The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention ftirther provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.

La présente invention concerne un procédé permettant de traiter certaines maladies à médiation des lymphocytes T, ainsi qu'un procédé permettant d'inhiber l'activation des lymphocytes T au moyen de certaines dicétopipérazines. L'invention concerne également des procédés pour la synthèse de dicétopipérazines, mais aussi certaines compositions comprenant certaines dicétopipérazines. L'invention concerne enfin des procédés pour la fabrication de compositions pharmaceutiques améliorées à base de protéines et de peptides, par augmentation ou diminution de la teneur en dicétopipérazines des compositions, ainsi que les compositions pharmaceutiques améliorées ainsi obtenues.

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