Treatment of tinnitus using neuroprotective agents

Details Treatment of tinnitus using neuroprotective agents Treatment of tinnitus using neuroprotective agents

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/453 (2006.01)

Patent

CA 2185512

Disclosed is a medicine for treating tinnitus in a mammal which comprises a therapeutically effective amount of a compound of the formula Image (I) (wherein: (a) R2 and R5 are taken separately and R1, R2, R3 and R4 are each independently hydrogen, C1-C6 alkyl, halo, CF3, OH or -OR7 and R5 is methyl or ethyl; or (b) R2 and R5 are taken together and are Image , forming a chroman- 4-ol ring, and R1, R3 and R4 are each independently hydrogen, C1-C6 alkyl, halo, CF3, OH or -OR7; R6 is Image , Image or Image ; R7 is methyl, ethyl, isopropyl or n-propyl; R8 is phenyl optionally substituted with up to three substituents independently selected from the group consisting of (C1-C6) alkyl, halo or CF3; X is O, S and (CH2)n; and n is 0, 1, 2 or 3) or a pharmaceutically acceptable salt thereof, and (2) a pharmaceutically acceptable carrier.

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