Treatment of tumors and new derivatives of .beta.-1,3- glucan

C - Chemistry – Metallurgy – 08 – B

Patent

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260/233, 260/225

C08B 37/00 (2006.01) C07H 3/04 (2006.01) C07H 3/06 (2006.01) C12P 19/04 (2006.01)

Patent

CA 1100951

Abstract of the Disclosure It has been found that water-insoluble, thermogelable .beta.-1,3-glucan produced by microorganisms, lower polymers obtainable upon partial hydrolysis of the glucan or, carboxy- methylated derivatives of said glucan or of said lower polymers are useful for inhibiting growth of tumors in warm-blooded animals, The inhibitory activity against various tumors of these poly- saccharides is very strong and significant whenever administered to warm-blooded animals from the early to very late stage of tumor progression or even when administered prior to plantation of tumors. The carboxythylated derivatives above-mentioned are novel water-soluble compounds which can be produced by carboxy- methylation of said glucan and partial hydrolyzate thereof.

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