A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 38/50 (2006.01) A61N 5/10 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2207974
A method of treating a tumor which comprises transducing tumor cells with a nucleic acid sequence encoding a negative selective marker (such as a viral thymidine kinase gene), and contacting the cells with an interaction agent (such as acyclovir, ganciclovir, or a halogenated pyrimidine). The cells then are exposed to radiation. Such method provides for increased killing of tumor cells as compared with gene therapy or radiation treatments alone.
L'invention concerne un procédé pour traiter une tumeur qui consiste à effectuer une transduction sur des cellules tumorales avec une séquence d'acide nucléique codant un marqueur sélectif négatif (tel qu'un gène viral de la thymidine kinase) et à mettre les cellules en contact avec un agent d'interaction (tel que acyclovir, ganciclovir, ou pyrimidine halogénée). Les cellules sont ensuite soumises à des radiations. Ce procédé permet d'augmenter la destruction des cellules tumorales par comparaison avec la thérapie génique seule ou la radiothérapie seule.
Freytag Svend
Kim Jae Ho
Kim San Hie
Henry Ford Hospital
Smart & Biggar
LandOfFree
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