A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2647671
The invention discloses methods of treatment of tumors that express oncogenic forms of the epidermal growth factor receptor (EGFR), such as EGFRvIII. The methods include testing of cancer patients for expression of EGFRvIII in their tumors, followed by treatment with a protein that contains antibody variable regions that recognize specific epitopes on the surface of the EGFR.
La présente invention concerne des procédés destinés au traitement des tumeurs exprimant les formes oncogéniques du récepteur du facteur de croissance de l'épiderme (EGFR), tel que le EGFRvIII. Les procédés consistent à détecter chez les patients atteints du cancer l'expression du EGFRvIII dans leurs tumeurs, puis à les traiter avec une protéine qui contient des régions variables d'anticorps reconnaissant des épitopes spécifiques sur la surface de l'EGFR.
Chao Ginger
Cresson Catherine
Lauffenburger Douglas
Way Jeffrey C.
Wittrup K. Dane
Emd Lexigen
Emd Serono Research Center Inc.
Gowling Lafleur Henderson Llp
Massachusetts Institute Of Technology
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