A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C12N 5/00 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2141935
Disclosed are methods and compositions for treating a neuroblastoma. The methods include contacting the neuroblastoma with a neurotrophic factor and less than a lethal dose of an inhibitor of cell proliferation for about 1 to 15 days, and then main- taining the neuroblastoma in contact with the neurotrophic factor for an additional 1 to 15 days. The composition includes a neu- rotrophic factor such as the neutropin, nerve growth factor, and an inhibitor of cell proliferation such as aphidicolin, thymi- dine, or hydroxyurea. Also disclosed are methods for inducing the remission or differentiation of, or eliminating, a neuroblasto- ma.
Lopresti Patrizia
Poluha Dorota
Poluha Wojciech
Ross Alonzo H.
Mbm & Co.
Worcester Foundation For Experimental Biology
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