Treatment of tumors with oligonucleotides directed to...

Details Treatment of tumors with oligonucleotides directed to... Treatment of tumors with oligonucleotides directed to...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339858

A method of inducing resistance to or regression of tumor growth comprising placing tumor cells in culture in vitro or ex vivo supplemented with a pro- apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a human for a therapeutically effective time, thereby inducing resistance to or regression of tumor growth.

La présente invention concerne un procédé permettant d'induire une résistance à la croissance tumorale ou une régression de la croissance tumorale. Ce procédé consiste à prendre des cellules tumorales et à les mettre en culture in vitro ou ex vivo avec en supplément un agent proapoptotique pendant un certain temps. Le procédé consiste ensuite à transférer ces cellules tumorales dans une chambre de diffusion, produisant ainsi une chambre contenant les cellules. Le procédé consiste enfin à introduire chez l'homme cette chambre pendant une période de traitement suffisante, ce qui induit une résistance à la croissance tumorale ou une régression de la croissance tumorale.

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