Treatment of vascular degenerative diseases by modulation of...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A23L 1/305 (2006.01) A61K 31/00 (2006.01) A61K 31/155 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/44 (2006.01) A61K 45/06 (2006.01) C12N 9/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2164632

Atherogenesis and restenosis are treated by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO inducted relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes. In addition, cells may be genetically engineered to provide a component in the synthetic pathway to nitric oxide, so as drive the process to enhance nitric oxide concentration, particularly in conjunction with the administration of a nitric oxide precursor.

On traite l'athérogénèse et la resténose en administrant à long terme des composés physiologiquement acceptables qui augmentent le taux d'oxyde nitrique endogène ou d'autres intermédiaires dans le processus de relaxation induit par NO chez l'hôte. D'autres composés de remplacement administrés seuls ou bien en association avec les précédents peuvent être administrés pour augmenter, sur une courte durée, le taux d'oxyde nitrique de manière directe ou par des processus physiologiques. En outre, des cellules peuvent être produites par génie génétique pour produire un composant dans le processus synthétique de l'oxyde nitrique de manière à stimuler le processus et augmenter la concentration d'oxyde nitrique, plus particulièrement en association avec l'administration d'un précurseur d'oxyde nitrique.

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