A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 33/00 (2006.01) A61K 38/44 (2006.01)
Patent
CA 2213188
Disclosed are methods of treating, inhibiting or preventing vascular thrombosis or arterial restenosis in a mammal. The disclosed methods include causing the mammal to inhale a therapeutically-effective concentration of gaseous nitric oxide (NO). Also disclosed are methods that include the administration of the following types of agents in conjunction with inhaled nitric oxide: compounds that potentiate the beneficial effects of inhaled nitric oxide, and antithrombotic agents that complement or supplement the beneficial effects of inhaled nitric oxide. The figure is a graph comparing the intima/media ratio in control rats, rats exposed for two weeks to 20 ppm NO, and rats exposed for one week to 80 ppm NO, followed by one week of breathing air. The asterisk indicates values significantly differing from baseline (p < 0.05).
On décrit des méthodes de traitement, d'inhibition ou de prévention de la thrombose vasculaire ou de la resténose artérielle chez un mammifère, lesquelles consistent à faire inhaler au mammifère une concentration efficace sur le plan thérapeutique d'oxyde nitrique (NO) gazeux. On décrit également des méthodes consistant en l'administration des types suivants d'agents conjointement avec l'oxyde nitrique inhalé: des composés qui potentialisent les effets bénéfiques de l'oxyde nitrique inhalé, ainsi que des agents anti-thrombotiques qui viennent compléter ou augmenter les effets bénéfiques de celui-ci. La figure est un graphe comparant le rapport intima/milieux chez des rats témoins, à savoir des rats exposés pendant deux semaines à 20 ppm d'oxyde nitrique et des rats exposés pendant une semaine à 80 ppm d'oxyde nitrique, ces semaines étant suivies d'une semaine pendant laquelle les rats ont respiré de l'air. L'astérisque indique les valeurs différant de manière significative de la ligne de base (p < 0,05).
Bloch Kenneth D.
Zapol Warren M.
Smart & Biggar
The General Hospital Corporation
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